Topoisomerase IIα

Synonyms

TopoII

  • Tech Only CPT
  • Tech Pro CPT
  • PowerPath Code
  • Schedule Monday - Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

This is a send out test.

Diagnostic Utility

Identifies: Topoisomerase II, an enzyme that winds and unwinds DNA to control the synthesis of proteins, and is the target of selected chemotherapy agents (e.g., etoposide, doxorubicin, etc.). Topoisomerase IIα may represent a predictive marker to determine response to anthracycline based chemotherapies.