TCL1

Synonyms

TCL1A, p14TCL1

  • Tech Only CPT
  • Tech Pro CPT
  • PowerPath Code
  • Schedule Monday - Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Disease State Blastic Plasmacytoid Dendritic Cell Neoplasm
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

This is a send out test.

Diagnostic Utility

Identifies a protein present in both the cytoplasm and nucleus of the following: immature normal T-cells; T-cell prolymphocytic leukemia (in which TCL-1 overexpression due to chromosomal translocation is the key pathogenetic event); a variety of B-cell lymphoproliferative disorders including CLL/SLL; and blastic plasmacytoid dendritic cell neoplasms.TCL-1 protein function has been studied predominately in T-cells, in which it has been demonstrated to bind to the AKT protooncogene and to enhance both AKT enzymatic activity and translocation from cytoplasm to nucleus.