Synaptophysin

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Chiefly used to detect neuroendocrine differentiation in specific neoplasms. Expressed in a variety of tissues including adrenal cortex and medulla, pancreatic islets, neuroendocrine cells of the carotid body, skin, pituitary, thyroid (c-cells), lung, pancreas, and GI tract, and paraganglia and is usually expressed in tumors arising from these tissues.