SMAD4

Synonyms

DPC4

  • Tech Only CPT 88342.TC
  • Tech Pro CPT
  • PowerPath Code SMAD4
  • Schedule Monday - Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

Smad4 is a tumor suppressor gene located at 18q21.1. It is inactivated in 55% of pancreatic adenocarcinomas and in 34% of carcinomas of the Ampulla of Vater but not in ampullary adenomas. Inactivation is manifested by loss of nuclear expression by immunohistochemistry.

Vendor

Santa Cruz Biotechnology, Inc.