PIN4 triple stain

Synonyms

Cocktail of AMACR (P504S), p63, and High Molecular Weight Cytokeratin

  • Tech Only CPT
  • Tech Pro CPT
  • PowerPath Code pin4
  • Schedule Monday to Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

PIN4 consists of a cocktail of three antibodies, including AMACR(P504S), p63, and high molecular weight cytokeratin. It is a triple stain that is useful in distinguishing prostatic adenocarcinoma (variable AMACR/P504S red cytoplasmic staining with a lack of basal cell p63+HMWK brown staining) from the benign mimickers (with preserved basal cell brown staining of p63+HMWK and generally lack of red cytoplasmic staining of AMACR/P504S).

Vendor

Biocare Medical and Novocastra /Leica Biosystems