PAX-5

Synonyms

BSAP; B-cell specific activator protein

  • Tech Only CPT 88342.TC
  • Tech Pro CPT
  • PowerPath Code PAX-5
  • Schedule Monday to Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

PAX-5 is expressed in all stages of B-cell development as early as pro-B-cells and it is down regulated (silenced) in plasma cell stage. It is a sensitive and specific pan-B-cell marker and it is expressed in the great majority of mature and immature B-cell neoplasms and nodular lymphocyte predominant Hodgkin lymphoma. It is also expressed at a low intensity in classical Hodgkin lymphoma.

Vendor

Biocare Medical