GATA3

Synonyms

GATA binding protein 3

  • Tech Only CPT 88342.TC
  • Tech Pro CPT
  • PowerPath Code GATA
  • Schedule Monday to Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

GATA3 is a nuclear zinc finger transcription factor, and is mainly used as a sensitive marker for breast and urothelial carcinomas when applied in a proper clinical setting. It may be especially helpful in triple-negative breast cancer and in high-grade urothelial carcinoma when other breast or urothelial markers are negative. GATA3 turns out to be not as specific for breast and urothelial carcinomas as originally anticipated, and other types of carcinomas, including squamous cell carcinoma, pancreatic and salivary gland ductal carcinomas, chromophobe renal cell carcinoma, and mesothelioma, etc. may show GATA3 reactivity to various extents. It labels T-lymphocytes, which serve as a good internal control.

Vendor

Cell Marque