Plasma Cell Panel

Container Type:Bone Marrow or Peripheral Blood in Heparin or EDTA. Tissue in RPMI or Sterile container with saline solution. Body Fluids in RPMI or Sterile container.

Preferred Volume:Bone Marrow or Peripheral Blood: 1.0 - 5.0ml Tissue: 1cm (greatest dimension) in 2ml of RPMI Body Fluids: 1.0-5.0ml

The plasma cell panel is designed to identify neoplastic plasma cells, which are present in disease processes ranging from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma. Plasma cells are identified on their very bright expression of the lymphocyte activation marker CD38. Cell-surface markers evaluated in this panel include CD19, CD20, CD45, CD56, and CD138. Because plasma cells generally express little or no surface immunoglobulin, this panel examines cytoplasmic kappa and lambda light chain expression in permeabilized cells to look for clonality.

1. Requisition form with the patient’s name, DOB, DOC and recent treatments.
2. CBC report for Peripheral Blood.

Bone Marrow and Peripheral Blood: 48-72hrs transport at room temperature. Tissue and Body Fluids: 24hrs. Transport refrigerated.

Specimens without 2 (two) patient identifiers. Incorrect anticoagulant or lack of anticoagulant, frozen or incorrectly stored specimens (i.e., excessive heat or cold), severely hemolyzed specimens (minimal hemolysis will be evaluated on a case-by-case basis), broken or leaking tubes, specimens received with needles affixed, submitted in fixative - no fixative is acceptable, specimen age: >72 hours for peripheral blood and >5 days for bone marrow *see note below, clotted specimens (small clots are acceptable-others evaluated on a case-by-case basis), contamination (bacterial, fungal, drug interaction, chylous, etc.), incorrectly labeled specimens or insufficient transport media for tissues and FNA’s.

*Note: Peripheral blood specimens >72-hours old are reported on a case-by-case basis and must be approved by the pathologist reviewing the case. Bone marrow specimens >5-days old are reported on a case-by-base basis and must be approved by the pathologist reviewing the case.

1 week.

These tests were developed and the performance characteristics determined by CellNetix Pathology & Laboratories. They have not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This laboratory is certified under CLIA-88 and is qualified to perform high complexity clinical testing. Prognostic and predictive testing should be interpreted in the context of additional clinical and/or histopathological findings.