High-Risk Human Papillomavirus
HPV, hrHPV
- Tech Only CPT 87624
- Tech Pro CPT
- PowerPath Code HPV HR Cobas
- Schedule Monday - Friday
- Turn Around Time Within 3 days of receipt
- Disease State Cervical Cancer, Cervical Dysplasia, Human Papillomavirus
- Methodology PCR
Organs
Specimen Requirements
ThinPrep vial containing a cervical/vaginal or anal specimen collected in PreservCyt. Minimum volume 1mL.
Clinical Significance
Persistent infection with Human Papillomavirus (HPV) is the principal cause of cervical cancer and its precursor cervical intraepithelial neoplasia.
Tests for High-Risk HPV subtypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68 without differentiation.
Required Patient Info
2 patient identifiers
Storage and Transportation
15°C - 30°C. Do not freeze.
Cause for Rejection
Improper collection medium (i.e., not in a ThinPrep vial), improper or inadequate patient identification, frozen specimens.
Retention
4 weeks from processing
Comments
Can be paired with HPV Genotyping 16 & 18. Detailed algorithms for the use of high-risk HPV DNA testing in various clinical scenarios is available at: http://www.asccp.org/Guidelines/Screening-Guidelines
Can be performed as:
HPV Regardless - Tests for HPV alongside cytology
HPV Reflex - Tests for HPV following an Atypical Squamous Cells of Undetermined Significance (ASCUS) cytology diagnosis
HPV Only - Tests for HPV without cytology. Cytology can be performed reflexively based on HPV results.